ApoA-I is a component of high-density lipoprotein (HDL). HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body's tissues to the liver. Once in the liver, cholesterol and phospholipids are redistributed to other tissues or removed from the body.

As a central constituent of HDL (high-density lipoprotein), apolipoprotein A-I (ApoA-I) has a vital function in lipid metabolism. Our previous studies confirmed that ApoA-I was differentially expressed in the adipose tissue of the abdomen of lean and fat broilers. The aim of the current work was to evaluate whether the transcription of ApoA-I in chicken abdominal adipose tissue was regulated

Sahlgrenska. Mycket talar för att kvoten mellan Cycas apoa är en kärlväxtart som beskrevs av Kenneth D. Hill. Cycas apoa ingår i släktet Cycas, och familjen Cycadaceae. IUCN kategoriserar arten globalt 2021-jan-16 - 1121 Likes, 2 Comments - APOA (@perioddramas_apoa) on Instagram: “Titanic (1997) Francis Fisher as Ruth DeWitt Bukater, mother to Kate Apoa Hotel, Yokkaichi: Se 45 recensioner, 12 bilder och bra erbjudanden på Apoa Hotel, rankat #11 av 28 hotell i Yokkaichi och med betyget 3,5 av 5 på I denna sakernas städning fann Apoa steln of högsta wigt att befästa Palestins ska kyrkan i den låropunkt , som annars låg dem så hårdt på hjertat ; nämligen att all ορνίθοφάγος , ον , ( φαγείν » ) ötande foglar af bovuw [ --- ] : fut .

Apolipoprotein A-I (ApoA-I) of high density lipoproteins (HDLs) is essential for the transportation of cholesterol between peripheral tissues and the liver. However, specific mutations in ApoA-I of HDLs are responsible for a late-onset systemic amyloidosis, the pathological accumulation of protein fibrils in tissues and organs. Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation. Many studies revealing alterations of ApoA-I during the development and progression of various types of cancer suggest that serum ApoA-I levels may represent a useful biomarker contributing to fenofibrate groups (P 0.0001) and apoA-I (P 0.001, both groups).

Indeed, the mAbs also recognized amyloid fibrils formed by α‐synuclein that has no sequence identity to apoA‐I. Thus, our newly generated anti‐apoA‐I fibril mAbs may be utilized for not only diagnosis of apoA‐I‐related amyloidosis but also structural analysis of amyloid fibrils as novel conformation‐selective antibodies.

Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation. Many studies revealing alterations of ApoA-I during the development and progression of various types of cancer suggest that serum ApoA-I levels may represent a useful biomarker contributing to 2021-01-01 · Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardial infarction 2013-01-03 · Dr. Remaley’s research has focused on the beneficial role of high-density lipoprotein (HDL), the so-called “good cholesterol.” HDL, which is a complex of the protein apoA-I with phospholipids, removes excess cholesterol from peripheral tissues, such as the arterial wall, and transports it to the liver and intestine for excretion from the (ApoA-I treated groups, 100 mg·kg−1 for ApoE−/− mice; 50 mg·kg−1 for Wrn mice), three times per week for 4 weeks.

The Iowa (G26R) mutation in human apolipoprotein A‐I (apoA‐I), the major protein of plasma high‐density lipoprotein, is associated with systemic amyloidosis, and the N‐terminal 1–83 fragment of apoA‐I carrying this mutation has a strong propensity to form amyloid fibrils.

We previously demonstrated that apolipoprotein A-I (apoA-I), the major protein component of high-density lipoprotein (HDL), is an important target for myeloperoxidase (MPO)-catalyzed tyrosine chlorination in the circulation of subjects with cardiovascular diseases. Oxidation of apoA-I by MPO has been reported to deprive HDL of its protective properties. However, the potential effects of MPO by apoA-I represents a major metabolic pathway of cellu-lar cholesterol efﬂux. ApoA-I belongs to a class of exchangeable apolipopro-teins that, under the appropriate conditions, can desorb from the surface of HDL particles into the aqueous phase (13). Lipid-free apoA-I can also be generated by the hy- N-apoA-I treatment lowered the number of circulating leukocytes by 30{plus minus}7% and their recruitment into the ischemic heart by 25{plus minus}10% (all p<5.0E-2). This was associated with a reduction in plasma levels of the clinical biomarker of cardiac injury, cardiac troponin-I by 52{plus minus}17% (p=1.01E-2).

Thus, our newly generated anti‐apoA‐I fibril mAbs may be utilized for not only diagnosis of apoA‐I‐related amyloidosis but also structural analysis of amyloid fibrils as novel conformation‐selective antibodies. The incidence of CHD is still increasing, which underscores the need for new preventive and therapeutic approaches to decrease CHD risk. In this respect, increasing apoA-I concentrations may be a promising approach, especially through increasing apoA-I synthesis. This review first provides insight into current knowledge on apoA-I production, clearance, and degradation, followed by a systematic Product filter.
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Apolipoprotein A-I (ApoA-I) is the major protein component of high-density lipoprotein (HDL), and is critical for maintenance of cholesterol homeostasis. During reverse cholesterol transport, HDL transitions between an array of subclasses, differing in size and composition. Human apolipoprotein (apo) A-I is a major heart-protective protein but its role in the brain pertinent to Alzheimer's disease has not been studied thoroughly. Several lines of evidence suggest that human apoA-I may have anti-Alzheimer's disease effects.

Olympus apoa i Apoa I, supplied by Olympus, used in various techniques.
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by apoA-I represents a major metabolic pathway of cellu-lar cholesterol efﬂux. ApoA-I belongs to a class of exchangeable apolipopro-teins that, under the appropriate conditions, can desorb from the surface of HDL particles into the aqueous phase (13). Lipid-free apoA-I can also be generated by the hy-

It has a specific role in lipid av L Zhu · 2017 · Citerat av 8 — Background: Apolipoprotein A-I (apoA-I) in high-density lipoprotein (HDL) is a key protein for the transport of cholesterol from the vascular wall to the liver. apoA-I Antibody (FL-267) is a rabbit polyclonal IgG; 200 µg/ml · Discontinued polyclonal antibody · See product citations (10). Robciuc, M. R., Metso, J., Sima, A., Ehnholm, C., & Jauhiainen, M. (2010). Human apoA-I increases macrophage foam cell derived PLTP activity without affecting Typ B: Analyser som föreslås öka i antal.